Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans
Identifieur interne : 000572 ( France/Analysis ); précédent : 000571; suivant : 000573Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans
Auteurs : Massimo Mangino [Royaume-Uni] ; Shih-Jen Hwang [États-Unis] ; Timothy D. Spector [Royaume-Uni] ; Steven C. Hunt [États-Unis] ; Masayuki Kimura [États-Unis] ; Annette L. Fitzpatrick [États-Unis] ; Lene Christiansen [Danemark] ; Inge Petersen [Danemark] ; Clara C. Elbers [États-Unis] ; Tamara Harris [États-Unis] ; WEI CHEN [États-Unis] ; Sathanur R. Srinivasan [États-Unis] ; Jeremy D. Kart [Israël] ; Athanase Benetos [France] ; Said El Shamieh [France] ; Sophie Visvikis-Siest [France] ; Kaare Christensen [Danemark] ; Gerald S. Berenson [États-Unis] ; Ana M. Valdes [Royaume-Uni] ; Ana Vinuela [Royaume-Uni] ; Melissa Garcia [États-Unis] ; Donna K. Arnett [États-Unis] ; Ulrich Broeckel [États-Unis] ; Michael A. Province [États-Unis] ; James S. Pankow [États-Unis] ; Candace Kammerer [États-Unis] ; YONGMEI LIU [États-Unis] ; Michael Nalls [États-Unis] ; Sarah Tishkoff [États-Unis] ; Fridtjof Thomas [États-Unis] ; Elad Ziv [États-Unis] ; Bruce M. Psaty [États-Unis] ; Joshua C. Bis [États-Unis] ; Jerome I. Rotter ; Kent D. Taylor ; Erin Smith ; Nicholas J. Schork ; Daniel Levy [États-Unis] ; Abraham Aviv [États-Unis]Source :
- Human molecular genetics : (Print) [ 0964-6906 ] ; 2012.
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Abstract
Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation. We performed a meta-analysis of 9190 individuals from six independent GWAS and validated our findings in 2226 individuals from four additional studies. We confirmed previously reported associations with OBFC1 (rs9419958 P = 9.1 × 10-11) and with the telomerase RNA component TERC (rs1317082, P = 1.1 x 10-8). We also identified two novel genomic regions associated with LTL variation that map near a conserved telomere maintenance complex component 1 (CTC1; rs3027234, P= 3.6 x 10-8) on chromosome17p13.1 and zinc finger protein 676 (ZNF676; rs412658, P = 3.3 x 10-8) on 19p12. The minor allele of rs3027234 was associated with both shorter LTL and lower expression of CTC1. Our findings are consistent with the recent observations that point mutations in CTC1 cause short telomeres in both Arabidopsis and humans affected by a rare Mendelian syndrome. Overall, our results provide novel insights into the genetic architecture of inter-individual LTL variation in the general population.
Affiliations:
- Danemark, France, Israël, Royaume-Uni, États-Unis
- Angleterre, Grand Est, Grand Londres, Lorraine (région), Missouri (État), Pennsylvanie, Washington (État)
- Londres, Nancy, Pittsburgh, Saint-Louis (Missouri), Seattle
- Université Washington de Saint-Louis, Université de Lorraine, Université de Pittsburgh, Université de Washington, École de médecine (Université Washington de Saint-Louis)
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Elbers</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Genetics, University of Pennsylvania, 415 Curie Boulevard</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA 19104</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Tamara" sort="Harris, Tamara" uniqKey="Harris T" first="Tamara" last="Harris">Tamara Harris</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging</s1><s2>Bethesda, MD 20892</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD 20892</wicri:noRegion></affiliation></author><author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans, LA 70118</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Orleans, LA 70118</wicri:noRegion></affiliation></author><author><name sortKey="Srinivasan, Sathanur R" sort="Srinivasan, Sathanur R" uniqKey="Srinivasan S" first="Sathanur R." last="Srinivasan">Sathanur R. Srinivasan</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans, LA 70118</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Orleans, LA 70118</wicri:noRegion></affiliation></author><author><name sortKey="Kart, Jeremy D" sort="Kart, Jeremy D" uniqKey="Kart J" first="Jeremy D." last="Kart">Jeremy D. 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Berenson</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans, LA 70118</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Orleans, LA 70118</wicri:noRegion></affiliation></author><author><name sortKey="Valdes, Ana M" sort="Valdes, Ana M" uniqKey="Valdes A" first="Ana M." last="Valdes">Ana M. Valdes</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Twin Research and Genetic Epidemiology, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Vinuela, Ana" sort="Vinuela, Ana" uniqKey="Vinuela A" first="Ana" last="Vinuela">Ana Vinuela</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Twin Research and Genetic Epidemiology, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging</s1><s2>Bethesda, MD 20892</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD 20892</wicri:noRegion></affiliation></author><author><name sortKey="Arnett, Donna K" sort="Arnett, Donna K" uniqKey="Arnett D" first="Donna K." last="Arnett">Donna K. Arnett</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Epidemiology, School of Public Health, University of Alabama at Birmingham</s1><s2>Birmingham, AL 35233</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Birmingham, AL 35233</wicri:noRegion></affiliation></author><author><name sortKey="Broeckel, Ulrich" sort="Broeckel, Ulrich" uniqKey="Broeckel U" first="Ulrich" last="Broeckel">Ulrich Broeckel</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Individualized Medicine Institute, Medical College of Wisconsin</s1><s2>WI 53226</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>WI 53226</wicri:noRegion></affiliation></author><author><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Division of Statistical Genomics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine</s1><s2>St Louis, MO 63110</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Division of Epidemiology and Community Health, University of Minnesota School of Public Health</s1><s2>Minneapolis, MN 55455</s2><s3>USA</s3><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Minneapolis, MN 55455</wicri:noRegion></affiliation></author><author><name sortKey="Kammerer, Candace" sort="Kammerer, Candace" uniqKey="Kammerer C" first="Candace" last="Kammerer">Candace Kammerer</name><affiliation wicri:level="4"><inist:fA14 i1="21"><s1>Department of Human Genetics, University of Pittsburgh</s1><s2>Pittsburgh, PA 15213</s2><s3>USA</s3><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Yongmei Liu" sort="Yongmei Liu" uniqKey="Yongmei Liu" last="Yongmei Liu">YONGMEI LIU</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Department of Epidemiology, WakeForest School of Medicine</s1><s2>Winston-Salem, NC 27150</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Winston-Salem, NC 27150</wicri:noRegion></affiliation></author><author><name sortKey="Nalls, Michael" sort="Nalls, Michael" uniqKey="Nalls M" first="Michael" last="Nalls">Michael Nalls</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging</s1><s2>Bethesda, MD 20892</s2><s3>USA</s3><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD 20892</wicri:noRegion></affiliation></author><author><name sortKey="Tishkoff, Sarah" sort="Tishkoff, Sarah" uniqKey="Tishkoff S" first="Sarah" last="Tishkoff">Sarah Tishkoff</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Genetics, University of Pennsylvania, 415 Curie Boulevard</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA 19104</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Fridtjof" sort="Thomas, Fridtjof" uniqKey="Thomas F" first="Fridtjof" last="Thomas">Fridtjof Thomas</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Preventive Medicine, The University of Tennessee Health Science Center</s1><s2>Memphis, TN 38105</s2><s3>USA</s3><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Memphis, TN 38105</wicri:noRegion></affiliation></author><author><name sortKey="Ziv, Elad" sort="Ziv, Elad" uniqKey="Ziv E" first="Elad" last="Ziv">Elad Ziv</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Department of Internal Medicine, University of California San Francisco</s1><s2>San Francisco, CA 94143</s2><s3>USA</s3><sZ>31 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Francisco, CA 94143</wicri:noRegion></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Epidemiology, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Medicine, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Health Services, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Group Health Research Institute, Group Health Cooperative</s1><s2>Seattle, WA 98101</s2><s3>USA</s3><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Seattle, WA 98101</wicri:noRegion></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name></author><author><name sortKey="Smith, Erin" sort="Smith, Erin" uniqKey="Smith E" first="Erin" last="Smith">Erin Smith</name></author><author><name sortKey="Schork, Nicholas J" sort="Schork, Nicholas J" uniqKey="Schork N" first="Nicholas J." last="Schork">Nicholas J. Schork</name></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Population Studies of the National Heart, Lung, and Blood Institute, Bethesda, MD and the Framingham Heart Study</s1><s2>Framingham MA 01701</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Framingham MA 01701</wicri:noRegion></affiliation></author><author><name sortKey="Aviv, Abraham" sort="Aviv, Abraham" uniqKey="Aviv A" first="Abraham" last="Aviv">Abraham Aviv</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>The Center of Human Development and Aging, New Jersey Medical School, UMDNJ</s1><s2>Newark, NJ 07103</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Newark, NJ 07103</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0035728</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 13-0035728 INIST</idno><idno type="RBID">Pascal:13-0035728</idno><idno type="wicri:Area/PascalFrancis/Corpus">002A17</idno><idno type="wicri:Area/PascalFrancis/Curation">001E85</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003487</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003487</idno><idno type="wicri:doubleKey">0964-6906:2012:Mangino M:genome:wide:meta</idno><idno type="wicri:Area/Main/Merge">009773</idno><idno type="wicri:Area/Main/Curation">009122</idno><idno type="wicri:Area/Main/Exploration">009122</idno><idno type="wicri:Area/France/Extraction">000572</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans</title><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Twin Research and Genetic Epidemiology, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Population Studies of the National Heart, Lung, and Blood Institute, Bethesda, MD and the Framingham Heart Study</s1><s2>Framingham MA 01701</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Framingham MA 01701</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Twin Research and Genetic Epidemiology, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hunt, Steven C" sort="Hunt, Steven C" uniqKey="Hunt S" first="Steven C." last="Hunt">Steven C. Hunt</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Cardiovascular Genetics Division, Department of Medicine, University of Utah</s1><s2>Salt Lake City, UT 84108</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Salt Lake City, UT 84108</wicri:noRegion></affiliation></author><author><name sortKey="Kimura, Masayuki" sort="Kimura, Masayuki" uniqKey="Kimura M" first="Masayuki" last="Kimura">Masayuki Kimura</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>The Center of Human Development and Aging, New Jersey Medical School, UMDNJ</s1><s2>Newark, NJ 07103</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Newark, NJ 07103</wicri:noRegion></affiliation></author><author><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Epidemiology, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Christiansen, Lene" sort="Christiansen, Lene" uniqKey="Christiansen L" first="Lene" last="Christiansen">Lene Christiansen</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Epidemiology, Institute of Public Health, University of Southern Denmark</s1><s2>Odense</s2><s3>DNK</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Petersen, Inge" sort="Petersen, Inge" uniqKey="Petersen I" first="Inge" last="Petersen">Inge Petersen</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Epidemiology, Institute of Public Health, University of Southern Denmark</s1><s2>Odense</s2><s3>DNK</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Elbers, Clara C" sort="Elbers, Clara C" uniqKey="Elbers C" first="Clara C." last="Elbers">Clara C. Elbers</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Genetics, University of Pennsylvania, 415 Curie Boulevard</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA 19104</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Tamara" sort="Harris, Tamara" uniqKey="Harris T" first="Tamara" last="Harris">Tamara Harris</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging</s1><s2>Bethesda, MD 20892</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD 20892</wicri:noRegion></affiliation></author><author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans, LA 70118</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Orleans, LA 70118</wicri:noRegion></affiliation></author><author><name sortKey="Srinivasan, Sathanur R" sort="Srinivasan, Sathanur R" uniqKey="Srinivasan S" first="Sathanur R." last="Srinivasan">Sathanur R. Srinivasan</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans, LA 70118</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Orleans, LA 70118</wicri:noRegion></affiliation></author><author><name sortKey="Kart, Jeremy D" sort="Kart, Jeremy D" uniqKey="Kart J" first="Jeremy D." last="Kart">Jeremy D. Kart</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Hebrew University-Hadassah School of Public Health</s1><s2>Jerusalem</s2><s3>ISR</s3><sZ>13 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Hebrew University-Hadassah School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Benetos, Athanase" sort="Benetos, Athanase" uniqKey="Benetos A" first="Athanase" last="Benetos">Athanase Benetos</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Geriatrics, Universite de Lorraine INSERM U961</s1><s2>Nancy</s2><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="El Shamieh, Said" sort="El Shamieh, Said" uniqKey="El Shamieh S" first="Said" last="El Shamieh">Said El Shamieh</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Unité de recherche 'Génétique Cardiovasculaire' EA-4373, Faculté de Pharmacie, Université de Lorraine</s1><s2>Nancy</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Visvikis Siest, Sophie" sort="Visvikis Siest, Sophie" uniqKey="Visvikis Siest S" first="Sophie" last="Visvikis-Siest">Sophie Visvikis-Siest</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Unité de recherche 'Génétique Cardiovasculaire' EA-4373, Faculté de Pharmacie, Université de Lorraine</s1><s2>Nancy</s2><s3>FRA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Christensen, Kaare" sort="Christensen, Kaare" uniqKey="Christensen K" first="Kaare" last="Christensen">Kaare Christensen</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Epidemiology, Institute of Public Health, University of Southern Denmark</s1><s2>Odense</s2><s3>DNK</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S." last="Berenson">Gerald S. Berenson</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans, LA 70118</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Orleans, LA 70118</wicri:noRegion></affiliation></author><author><name sortKey="Valdes, Ana M" sort="Valdes, Ana M" uniqKey="Valdes A" first="Ana M." last="Valdes">Ana M. Valdes</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Twin Research and Genetic Epidemiology, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Vinuela, Ana" sort="Vinuela, Ana" uniqKey="Vinuela A" first="Ana" last="Vinuela">Ana Vinuela</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Twin Research and Genetic Epidemiology, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging</s1><s2>Bethesda, MD 20892</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD 20892</wicri:noRegion></affiliation></author><author><name sortKey="Arnett, Donna K" sort="Arnett, Donna K" uniqKey="Arnett D" first="Donna K." last="Arnett">Donna K. Arnett</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Epidemiology, School of Public Health, University of Alabama at Birmingham</s1><s2>Birmingham, AL 35233</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Birmingham, AL 35233</wicri:noRegion></affiliation></author><author><name sortKey="Broeckel, Ulrich" sort="Broeckel, Ulrich" uniqKey="Broeckel U" first="Ulrich" last="Broeckel">Ulrich Broeckel</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Individualized Medicine Institute, Medical College of Wisconsin</s1><s2>WI 53226</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>WI 53226</wicri:noRegion></affiliation></author><author><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Division of Statistical Genomics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine</s1><s2>St Louis, MO 63110</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Division of Epidemiology and Community Health, University of Minnesota School of Public Health</s1><s2>Minneapolis, MN 55455</s2><s3>USA</s3><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Minneapolis, MN 55455</wicri:noRegion></affiliation></author><author><name sortKey="Kammerer, Candace" sort="Kammerer, Candace" uniqKey="Kammerer C" first="Candace" last="Kammerer">Candace Kammerer</name><affiliation wicri:level="4"><inist:fA14 i1="21"><s1>Department of Human Genetics, University of Pittsburgh</s1><s2>Pittsburgh, PA 15213</s2><s3>USA</s3><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Yongmei Liu" sort="Yongmei Liu" uniqKey="Yongmei Liu" last="Yongmei Liu">YONGMEI LIU</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Department of Epidemiology, WakeForest School of Medicine</s1><s2>Winston-Salem, NC 27150</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Winston-Salem, NC 27150</wicri:noRegion></affiliation></author><author><name sortKey="Nalls, Michael" sort="Nalls, Michael" uniqKey="Nalls M" first="Michael" last="Nalls">Michael Nalls</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging</s1><s2>Bethesda, MD 20892</s2><s3>USA</s3><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD 20892</wicri:noRegion></affiliation></author><author><name sortKey="Tishkoff, Sarah" sort="Tishkoff, Sarah" uniqKey="Tishkoff S" first="Sarah" last="Tishkoff">Sarah Tishkoff</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Genetics, University of Pennsylvania, 415 Curie Boulevard</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA 19104</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Fridtjof" sort="Thomas, Fridtjof" uniqKey="Thomas F" first="Fridtjof" last="Thomas">Fridtjof Thomas</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Preventive Medicine, The University of Tennessee Health Science Center</s1><s2>Memphis, TN 38105</s2><s3>USA</s3><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Memphis, TN 38105</wicri:noRegion></affiliation></author><author><name sortKey="Ziv, Elad" sort="Ziv, Elad" uniqKey="Ziv E" first="Elad" last="Ziv">Elad Ziv</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Department of Internal Medicine, University of California San Francisco</s1><s2>San Francisco, CA 94143</s2><s3>USA</s3><sZ>31 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Francisco, CA 94143</wicri:noRegion></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Epidemiology, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Medicine, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Health Services, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Group Health Research Institute, Group Health Cooperative</s1><s2>Seattle, WA 98101</s2><s3>USA</s3><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Seattle, WA 98101</wicri:noRegion></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1><s2>Seattle, WA 98195</s2><s3>USA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name></author><author><name sortKey="Smith, Erin" sort="Smith, Erin" uniqKey="Smith E" first="Erin" last="Smith">Erin Smith</name></author><author><name sortKey="Schork, Nicholas J" sort="Schork, Nicholas J" uniqKey="Schork N" first="Nicholas J." last="Schork">Nicholas J. Schork</name></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Population Studies of the National Heart, Lung, and Blood Institute, Bethesda, MD and the Framingham Heart Study</s1><s2>Framingham MA 01701</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Framingham MA 01701</wicri:noRegion></affiliation></author><author><name sortKey="Aviv, Abraham" sort="Aviv, Abraham" uniqKey="Aviv A" first="Abraham" last="Aviv">Abraham Aviv</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>The Center of Human Development and Aging, New Jersey Medical School, UMDNJ</s1><s2>Newark, NJ 07103</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Newark, NJ 07103</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Human molecular genetics : (Print)</title><title level="j" type="abbreviated">Hum. mol. genet. : (Print)</title><idno type="ISSN">0964-6906</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Human molecular genetics : (Print)</title><title level="j" type="abbreviated">Hum. mol. genet. : (Print)</title><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene</term><term>Genetics</term><term>Homeostasis</term><term>Human</term><term>Metaanalysis</term><term>Telomere</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Métaanalyse</term><term>Gène</term><term>Génétique</term><term>Télomère</term><term>Homéostasie</term><term>Homme</term><term>Echelle du génome</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation. We performed a meta-analysis of 9190 individuals from six independent GWAS and validated our findings in 2226 individuals from four additional studies. We confirmed previously reported associations with OBFC1 (rs9419958 P = 9.1 × 10<sup>-11</sup>) and with the telomerase RNA component TERC (rs1317082, P = 1.1 x 10<sup>-8</sup>). We also identified two novel genomic regions associated with LTL variation that map near a conserved telomere maintenance complex component 1 (CTC1; rs3027234, P= 3.6 x 10-<sup>8</sup>) on chromosome17p13.1 and zinc finger protein 676 (ZNF676; rs412658, P = 3.3 x 10<sup>-8</sup>) on 19p12. The minor allele of rs3027234 was associated with both shorter LTL and lower expression of CTC1. Our findings are consistent with the recent observations that point mutations in CTC1 cause short telomeres in both Arabidopsis and humans affected by a rare Mendelian syndrome. Overall, our results provide novel insights into the genetic architecture of inter-individual LTL variation in the general population.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>France</li><li>Israël</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Est</li><li>Grand Londres</li><li>Lorraine (région)</li><li>Missouri (État)</li><li>Pennsylvanie</li><li>Washington (État)</li></region><settlement><li>Londres</li><li>Nancy</li><li>Pittsburgh</li><li>Saint-Louis (Missouri)</li><li>Seattle</li></settlement><orgName><li>Université Washington de Saint-Louis</li><li>Université de Lorraine</li><li>Université de Pittsburgh</li><li>Université de Washington</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><noCountry><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><name sortKey="Schork, Nicholas J" sort="Schork, Nicholas J" uniqKey="Schork N" first="Nicholas J." last="Schork">Nicholas J. Schork</name><name sortKey="Smith, Erin" sort="Smith, Erin" uniqKey="Smith E" first="Erin" last="Smith">Erin Smith</name><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name></region><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><name sortKey="Valdes, Ana M" sort="Valdes, Ana M" uniqKey="Valdes A" first="Ana M." last="Valdes">Ana M. Valdes</name><name sortKey="Vinuela, Ana" sort="Vinuela, Ana" uniqKey="Vinuela A" first="Ana" last="Vinuela">Ana Vinuela</name></country><country name="États-Unis"><noRegion><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name></noRegion><name sortKey="Arnett, Donna K" sort="Arnett, Donna K" uniqKey="Arnett D" first="Donna K." last="Arnett">Donna K. Arnett</name><name sortKey="Aviv, Abraham" sort="Aviv, Abraham" uniqKey="Aviv A" first="Abraham" last="Aviv">Abraham Aviv</name><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S." last="Berenson">Gerald S. Berenson</name><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><name sortKey="Broeckel, Ulrich" sort="Broeckel, Ulrich" uniqKey="Broeckel U" first="Ulrich" last="Broeckel">Ulrich Broeckel</name><name sortKey="Elbers, Clara C" sort="Elbers, Clara C" uniqKey="Elbers C" first="Clara C." last="Elbers">Clara C. Elbers</name><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><name sortKey="Harris, Tamara" sort="Harris, Tamara" uniqKey="Harris T" first="Tamara" last="Harris">Tamara Harris</name><name sortKey="Hunt, Steven C" sort="Hunt, Steven C" uniqKey="Hunt S" first="Steven C." last="Hunt">Steven C. Hunt</name><name sortKey="Kammerer, Candace" sort="Kammerer, Candace" uniqKey="Kammerer C" first="Candace" last="Kammerer">Candace Kammerer</name><name sortKey="Kimura, Masayuki" sort="Kimura, Masayuki" uniqKey="Kimura M" first="Masayuki" last="Kimura">Masayuki Kimura</name><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><name sortKey="Nalls, Michael" sort="Nalls, Michael" uniqKey="Nalls M" first="Michael" last="Nalls">Michael Nalls</name><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><name sortKey="Srinivasan, Sathanur R" sort="Srinivasan, Sathanur R" uniqKey="Srinivasan S" first="Sathanur R." last="Srinivasan">Sathanur R. Srinivasan</name><name sortKey="Thomas, Fridtjof" sort="Thomas, Fridtjof" uniqKey="Thomas F" first="Fridtjof" last="Thomas">Fridtjof Thomas</name><name sortKey="Tishkoff, Sarah" sort="Tishkoff, Sarah" uniqKey="Tishkoff S" first="Sarah" last="Tishkoff">Sarah Tishkoff</name><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><name sortKey="Yongmei Liu" sort="Yongmei Liu" uniqKey="Yongmei Liu" last="Yongmei Liu">YONGMEI LIU</name><name sortKey="Ziv, Elad" sort="Ziv, Elad" uniqKey="Ziv E" first="Elad" last="Ziv">Elad Ziv</name></country><country name="Danemark"><noRegion><name sortKey="Christiansen, Lene" sort="Christiansen, Lene" uniqKey="Christiansen L" first="Lene" last="Christiansen">Lene Christiansen</name></noRegion><name sortKey="Christensen, Kaare" sort="Christensen, Kaare" uniqKey="Christensen K" first="Kaare" last="Christensen">Kaare Christensen</name><name sortKey="Petersen, Inge" sort="Petersen, Inge" uniqKey="Petersen I" first="Inge" last="Petersen">Inge Petersen</name></country><country name="Israël"><noRegion><name sortKey="Kart, Jeremy D" sort="Kart, Jeremy D" uniqKey="Kart J" first="Jeremy D." last="Kart">Jeremy D. Kart</name></noRegion></country><country name="France"><region name="Grand Est"><name sortKey="Benetos, Athanase" sort="Benetos, Athanase" uniqKey="Benetos A" first="Athanase" last="Benetos">Athanase Benetos</name></region><name sortKey="El Shamieh, Said" sort="El Shamieh, Said" uniqKey="El Shamieh S" first="Said" last="El Shamieh">Said El Shamieh</name><name sortKey="Visvikis Siest, Sophie" sort="Visvikis Siest, Sophie" uniqKey="Visvikis Siest S" first="Sophie" last="Visvikis-Siest">Sophie Visvikis-Siest</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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